TL-2018-121 - Research Associate Proteomic Mass Spectrometry (M/F)

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Posted: 27/08/2018 15:55
Start Date: Not Available
Salary: To be determined
Location: Toulouse
Level: Technical
Deadline: 31/12/2018 23:59
Hours: 37
Benefits: To be determined
Job Type: Full Time, Temporary

Evotec is a drug discovery solutions company providing drug discovery expertise and

capabilities to pharmaceutical and biotechnology companies as well as to academic institutions. Drug discovery solutions are provided in form of fee-for-service work, integrated drug discovery alliances, development partnerships, licensing of innovative

drug candidates and consulting arrangements. The Company operates worldwide and has leading scientific experts, state-of-the-art technologies as well as key therapeutic expertise in the areas of neuroscience, pain, metabolic diseases, oncology, inflammation and infectious diseases. By leveraging this expertise, Evotec intends to develop best-in class and first-in-class differentiated therapeutics on its systematic, unbiased and comprehensive infrastructure.

Evotec is built on integrated drug discovery know-how of 20 years and is a leading player in the drug discovery field. The Company’s headquarters are located in Hamburg, Germany. Additional major operating sites exist in UK, Germany, France, Italy, Swiss and USA, and we have more than 2000 employees worldwide.

Evotec offers unique innovative proteomics services to address key issues in drug and biomarker discovery and continuously advance capabilities in mass spectrometry-based proteomics to ensure unrivalled comprehensiveness and data quality when analyzing cells, animal models and patient samples. Both the expertise and the data processing infrastructure are in place for accurate quantification across many different samples (primary or cultured cells, animal or patient tissues, and body fluids), enabling integrated, large-scale projects to discover and validate diagnostic, pharmacodynamic or predictive biomarkers in many different disease areas.

For our site in Toulouse, France, we have an exciting opportunity for a dedicated and professional

Research Associate Proteomic Mass Spectrometry (M/F)

Temporary contract (12 months)

We are seeking an accomplished scientist to join our proteomics group based at our Toulouse site with a strong expertise in mass spectrometry (MS) and quantitative proteomics. The candidate will join a talented team of scientists to develop and use fit-for-purpose MS-based proteomic analyses of biological samples to support pre-clinical or clinical target and biomarker discovery programs for our customers and partners. She/he should be a highly motivated, creative scientist with extensive expertise and strong track record of success in protein biochemistry and MS-based proteomics. Experience with high-resolution mass spectrometers such as the Q Exactive class instruments (Thermo Fischer) is required. The candidate should also have extensive knowledge of analytical software for the processing and interpretation of quantitative mass spectrometry data, familiarity with programming languages and database software being a plus. The candidate will work closely with the senior scientist in charge of the proteomic platform to expand current capabilities of sample processing, LC/MS operation, and data analysis. She/he will also collaborate with other teams within interdisciplinary research projects. Preference will be given to candidates who have a proven track record to successfully manage research projects and deliver on project goals.

Your key responsibilities include:

  • Plan and oversee MS measurements, quantitative MS data analysis and interpretation.
  • Provide leadership for various operational tasks within the laboratory including use of Q Exactive class instruments.
  • Develop and implement state-of-the-art mass spectrometry-based analytical techniques to identify and characterize proteins, peptides, post-translational modifications of proteins and, protein-ligand complexes.
  • Contribute to the development of customized tools for mass spectrometric quantitative analyses tailored to the specific project needs
  • Proactively evaluate new MS technologies, be versed with current literature, and implement new methods into the mass spectrometry assay/analytical pipeline as necessary.
  • Communicate effectively with clients and internally through written and oral communication and presentations.
  • Demonstrate excellent organization/multitasking, communication and analytical skills.
  • Demonstrate strong problem-solving and project management capabilities.
  • Closely collaborate with other teams within the proteomic group as well as with interdisciplinary project teams.
  • Supervise technicians.

Your ideal qualification:

  • MD in analytical chemistry, biochemistry, biology or related field with background in protein and peptide mass spectrometry.
  • 3+ years of research experience in mass spectrometry-based proteomics technology in the private sector or academia.
  • Solid hands-on expertise in quantitative mass spectrometry proteomics (SILAC, label-free, TMT) and MS data analysis using dedicated software (i.e. MaxQuant) and appropriate statistical methods.
  • Experience with targeted proteomics (MRM, PRM) and MS data analysis using dedicated software (i.e. Skyline).
  • Demonstrated success and creativity as evidenced by a strong record of scientific accomplishments.
  • Excellent project management skills.
  • Ability to perform within a matrixed organization and in a fast-paced work environment.
  • Strong interpersonal, verbal and written communication skills.

Desirable Knowledge, Skills and Abilities:

  • Experience with quantitative mass spectrometry analysis with Q Exactive class instruments.
  • Experience with targeted proteomics (MRM, PRM).
  • Experience with data-independent acquisition mass spectrometry is an advantage.
  • Experience with analysis of quantitative proteomics data.
  • Scientific rigor and excellent analytical capabilities.
  • Capability to work with interdisciplinary teams.
  • Strong communication skills and ability to communicate effectively with clients.
  • Dynamic personality with passion for innovation and problem-solving and a willingness to apply core areas of knowledge to new areas of interest to Evotec and its clients.
  • Fluent English, a commitment to master French language in a timely manner is expected


Evotec offers the chance to expand and develop your career in an exciting professional environment promoted by an open culture and a spirit of community

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